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全部產(chǎn)品分類(lèi)
品牌 |
Leading Biology | 貨號(hào) |
APR08105G |
產(chǎn)品分類(lèi) |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KLHL22 antibody.
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分子量 |
72kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Mainly. cytoplasmic in prophase and prometaphase. Associates with the mitotic spindle as the cells reach chromosome bi-orientation. Localizes to the centrosomes shortly before cells enter anaphase After anaphase onset, predominantly associates with the polar microtubules connecting the 2 opposing centrosomes and gradually diffuses into the cytoplasm during telophase
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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克隆號(hào) |
7B10
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亞型 |
IgG1
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基因ID |
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UniProt ID |
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功能 |
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of PLK1 at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. Monoubiquitination of PLK1 does not lead to PLK1 degradation.
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形式 |
Liquid. In PBS containing 0.02% sodium azide.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, ICC, E
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稀釋方法 |
WB~~1/500 - 1/2000
IF~~1/200 - 1/1000
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別名 |
Kelch-like protein 22, KLHL22
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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