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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > EphA7 Antibody

EphA7 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR15831G 100 μl / ¥4950

EphA7 Antibody

品牌

Leading Biology

貨號(hào)

APR15831G

產(chǎn)品分類

Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality EphA7 antibody.

分子量

112097 Da

細(xì)胞定位

Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein

宿主

Mouse

種屬反應(yīng)性

Human

克隆號(hào)

6C8G7

亞型

IgG2b

通用名

EHK3, HEK11

基因ID

UniProt ID

功能

Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7.

形式

Liquid. In PBS containing 0.02% sodium azide.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC, E

稀釋方法

WB~~1/500 - 1/2000 IHC~~1/200 - 1/1000

別名

Ephrin type-A receptor 7, 2.7.10.1, EPH homology kinase 3, EHK-3, EPH-like kinase 11, EK11, hEK11, EPHA7, EHK3, HEK11

圖像

Figure 1: Western blot analysis using EphA7 mouse mAb against truncated GST-EphA7 recombinant protein (1) and truncated EphA7 (aa25-556)-hIgGFc transfected CHOK1 cell lysate (2).

Figure 2: Immunohistochemical analysis of paraffin-embedded human Breast tissues using EPHA7 mouse mAb

說(shuō)明書

數(shù)量

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