品牌 |
Leading Biology | 貨號(hào) |
APR17594G |
產(chǎn)品分類(lèi) |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NR0B2 antibody (monoclonal) (M01).
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分子量 |
28058 Da
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宿主 |
mouse
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
NR0B2 (AAH30207, 1 a.a. ~ 257 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
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克隆號(hào) |
1A11
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亞型 |
IgG2a Kappa
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基因ID |
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UniProt ID |
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總結(jié) |
The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function.
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形式 |
Clear, colorless solution in phosphate buffered saline, pH 7.2 .
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IF, E
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稀釋方法 |
WB~~1:500~1000
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別名 |
Nuclear receptor subfamily 0 group B member 2, Orphan nuclear receptor SHP, Small heterodimer partner, NR0B2, SHP
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圖像 |
NR0B2 monoclonal antibody (M01), clone 1A11. Western Blot analysis of NR0B2 expression in human colon. Immunofluorescence of monoclonal antibody to NR0B2 on HeLa cell . [antibody concentration 10 ug/ml] Detection limit for recombinant GST tagged NR0B2 is approximately 3ng/ml as a capture antibody. |
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說(shuō)明書(shū) |
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數(shù)量 |
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