CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody - Without BSA and Azide

APR07313G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR07313G		100 μg / ￥4950

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CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody - Without BSA and Azide

品牌	Leading Biology	貨號(hào)	APR07313G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) antibody - Without BSA and Azide.
分子量	~165kDa
細(xì)胞定位	Antigen Cellular Localization: Mitochondrion. Nucleus, nucleolus
宿主	Mouse
種屬反應(yīng)性	Human, Dog
克隆號(hào)	SPM615
亞型	Mouse / IgG1
基因ID	1373
UniProt ID	P31327
功能	Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell.
總結(jié)	This MAb recognizes a protein of 165kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.?Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC, IF
別名	Carbamoyl-phosphate synthase [ammonia], mitochondrial, 6.3.4.16, Carbamoyl-phosphate synthetase I, CPSase I, CPS1
圖像	Formalin-fixed, paraffin-embedded human Hepatocellular Carcinoma stained with CPS1 Monoclonal Antibody (SPM615).
說(shuō)明書(shū)	Product Datasheet Protocol
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CPS1 / Carbamoyl-Phosphate Synthetase (Hepatocellular Marker) Antibody - Without BSA and Azide