NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker) Antibody

APG03078G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APG03078G		7 ml / ￥4950

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安諾倫（北京）生物科技有限公司

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NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker) Antibody

品牌	Leading Biology	貨號(hào)	APG03078G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker) antibody.
分子量	40-50kDa
細(xì)胞定位	Antigen Cellular Localization: Nucleus {ECO:0000255\|PROSITE- ProRule:PRU00108}
宿主	Mouse
種屬反應(yīng)性	Human, Mouse, Chicken
克隆號(hào)	NX2/294
亞型	Mouse / IgG2b, kappa
通用名	NKX2.2, NKX2B
基因ID	4821
UniProt ID	O95096
功能	Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity).
總結(jié)	Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.
形式	Liquid. In PBS containing 0.02% sodium azide.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC, IF, FC
別名	Homeobox protein Nkx-2.2, Homeobox protein NK-2 homolog B, NKX2-2, NKX2.2, NKX2B
圖像	Formalin-fixed, paraffin-embedded human Ewing's Sarcoma stained with NKX2.2 Monoclonal Antibody (NX2/294). Formalin-fixed, paraffin-embedded human Pancreas stained with NKX2.2 Monoclonal Antibody (NX2/294). Formalin-fixed, paraffin-embedded Rat Pancreas stained with NKX2.2 Monoclonal Antibody (NX2/294).
說(shuō)明書(shū)	Product Datasheet Protocol
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NKX2.2 (Neuroendocrine & Ewing's Sarcoma Marker) Antibody