全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR09971G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SIRT6 antibody.
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分子量 |
39 KDa
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細胞定位 |
Antigen Cellular Localization:
Nucleus, nucleoplasm. Note=Predominantly nuclear Associated with telomeric heterochromatin regions
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宿主 |
Mouse
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通用名 |
SIR2L6
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基因ID |
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UniProt ID |
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功能 |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
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總結(jié) |
NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span (By similarity). Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate.
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形式 |
Purified mouse monoclonal in PBS(pH 7.4)containing with 0.02% sodium azide,50% glycerol.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:500
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別名 |
2810449N18Rik;AI043036;Mono ADP ribosyltransferase sirtuin 6;NAD-dependent deacetylase sirtuin-6;NAD-dependent protein deacetylase sirtuin-6;Regulatory protein SIR2 homolog;SIR2 like 6;SIR2 like protein 6;Sir2 related protein type 6;SIR2-like protein 6;SIR2L6;SIRT 6;SIRT6;SIRT6_HUMAN;Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae);Sirtuin 6;Sirtuin type 6;Sirtuin6.
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圖像 |
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說明書 |
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數(shù)量 |
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