全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APG02872G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CYP1A2 antibody.
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分子量 |
58294 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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免疫原 |
255-282 aa
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靶點 |
This CYP1A2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 255-282 amino acids from human CYP1A2.
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克隆號 |
499CT13.2.2
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亞型 |
IgG3
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基因ID |
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UniProt ID |
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功能 |
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Most active in catalyzing 2-hydroxylation. Caffeine is metabolized primarily by cytochrome CYP1A2 in the liver through an initial N3-demethylation. Also acts in the metabolism of aflatoxin B1 and acetaminophen. Participates in the bioactivation of carcinogenic aromatic and heterocyclic amines. Catalizes the N-hydroxylation of heterocyclic amines and the O- deethylation of phenacetin.
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總結(jié) |
This gene encodes a member of the cytochrome P450superfamily of enzymes. The cytochrome P450 proteins aremonooxygenases which catalyze many reactions involved in drugmetabolism and synthesis of cholesterol, steroids and other lipids.The protein encoded by this gene localizes to the endoplasmicreticulum and its expression is induced by some polycyclic aromatichydrocarbons (PAHs), some of which are found in cigarette smoke.The enzyme's endogenous substrate is unknown; however, it is ableto metabolize some PAHs to carcinogenic intermediates. Otherxenobiotic substrates for this enzyme include caffeine, aflatoxinB1, and acetaminophen. The transcript from this gene contains fourAlu sequences flanked by direct repeats in the 3' untranslatedregion.
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形式 |
Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:100~250
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別名 |
Cytochrome P450 1A2, CYPIA2, Cytochrome P(3)450, Cytochrome P450 4, Cytochrome P450-P3, CYP1A2
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圖像 |
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說明書 |
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數(shù)量 |
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