FGA Antibody (N-term)

AMM04535G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM04535G		100 μl / ￥4950

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FGA Antibody (N-term)

品牌	Leading Biology	貨號	AMM04535G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FGA antibody (N-term).
分子量	94973 Da
細(xì)胞定位	Antigen Cellular Localization: Secreted.
宿主	Mouse
種屬反應(yīng)性	Human, Mouse
免疫原	420-448 aa
靶點(diǎn)	This FGA antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 420-448 amino acids from the N-terminal region of human FGA.
克隆號	471CT12.1.2
亞型	IgM
基因ID	2243
UniProt ID	P02671
功能	Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3- dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
總結(jié)	The protein encoded by this gene is the alpha component offibrinogen, a blood-borne glycoprotein comprised of three pairs ofnonidentical polypeptide chains. Following vascular injury,fibrinogen is cleaved by thrombin to form fibrin which is the mostabundant component of blood clots. In addition, various cleavageproducts of fibrinogen and fibrin regulate cell adhesion andspreading, display vasoconstrictor and chemotactic activities, andare mitogens for several cell types. Mutations in this gene lead toseveral disorders, including dysfibrinogenemia, hypofibrinogenemia,afibrinogenemia and renal amyloidosis. Alternative splicing resultsin two isoforms which vary in the carboxy-terminus. [provided byRefSeq].
形式	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:100~500
別名	Fibrinogen alpha chain, Fibrinopeptide A, Fibrinogen alpha chain, FGA
圖像	Western blot analysis of lysates from human Liver, mouse Liver, mouse bladder tissue (from left to right), using FGA Antibody (N-term)( AMM04535G). AMM04535G was diluted at 1:1000 at each lane. A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody. Lysates at 20μg per lane. FGA Antibody (N-term) (Cat. AMM04535G) western blot analysis in mouse bladder tissue lysates (35μg/lane).This demonstrates the FGA(N-term) antibody detected the FGA(N-term) protein (arrow).
說明書	Product Datasheet Protocol
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