RAB8A Antibody

AMM07495G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM07495G		100 μl / ￥4950

大規(guī)格詢價(jià)

2 Images

訂購(gòu)信息

安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
Inquiry@annoron.com

全國(guó)授權(quán)代理商

RAB8A Antibody

品牌	Leading Biology	貨號(hào)	AMM07495G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RAB8A antibody.
分子量	23668 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus Recycling endosome membrane. Cell projection, cilium. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP- bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP- bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Localizes to tubular recycling endosome. Recruited to phagosomes containing S.aureus or M.tuberculosis
宿主	Mouse
種屬反應(yīng)性	Human, Mouse
靶點(diǎn)	This RAB8A monoclonal antibody is generated from mouse immunized with RAB8A recombinant protein.
克隆號(hào)	261CT1.3.1
亞型	IgG1,k
通用名	MEL, RAB8
基因ID	4218
UniProt ID	P61006
功能	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization. Plays an important role in ciliogenesis. Together with MICALL2, may also regulate adherens junction assembly. May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis.
總結(jié)	The protein encoded by this gene is a member of the RASsuperfamily which are small GTP/GDP-binding proteins with anaverage size of 200 amino acids. The RAS-related proteins of theRAB/YPT family may play a role in the transport of proteins fromthe endoplasmic reticulum to the Golgi and the plasma membrane.This protein shares 97%, 96%, and 51% similarity with the dog RAB8,mouse MEL, and mouse YPT1 proteins, respectively and contains the 4GTP/GDP-binding sites that are present in all the RAS proteins. Theputative effector-binding site of this protein is similar to thatof the RAB/YPT proteins. However, this protein contains aC-terminal CAAX motif that is characteristic of many RASsuperfamily members but which is not found in YPT1 and the majorityof RAB proteins. Although this gene was isolated as a transforminggene from a melanoma cell line, no linkage between MEL andmalignant melanoma has been demonstrable. This oncogene is located800 kb distal to MY09B on chromosome 19p13.1.
形式	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:100
別名	Ras-related protein Rab-8A, Oncogene c-mel, RAB8A, MEL, RAB8
圖像	All lanes : Anti-RAB8A Antibody at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: HCT116 whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-mouse IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 24 kDa Blocking/Dilution buffer: 5% NFDM/TBST. RAB8A Antibody (Cat. AMM07495G) western blot analysis in mouse brain tissue lysates (35μg/lane).This demonstrates the RAB8A antibody detected the RAB8A protein (arrow).
說(shuō)明書	Product Datasheet Protocol
數(shù)量

加入購(gòu)物車詢價(jià)

上一產(chǎn)品：LHX2 Antibody 下一產(chǎn)品：CD20 / MS4A1 (B-Cell Marker) Antibody - Culture Supernatant

熱銷產(chǎn)品

產(chǎn)品添加成功！

購(gòu)物車已有 0 件產(chǎn)品

繼續(xù)訂購(gòu) 查看訂購(gòu)單

加入詢價(jià)單成功！

詢價(jià)單已有 0 件產(chǎn)品

繼續(xù)詢價(jià) 查看詢價(jià)單

選擇	品牌	貨號(hào)	產(chǎn)品名稱	規(guī)格	分類	研究領(lǐng)域	說(shuō)明書	數(shù)量	目錄價(jià)
1	Leading Biology	APG01369G	VEGF (Vascular Endothelial Growth Factor) Antibody - Without BSA and Azide	100 μg	Monoclonal Antibodies				￥4950.00	訂購(gòu) 詢價(jià)
2	Leading Biology	AMM07627G	RIN2 Antibody (monoclonal) (M01)	100 μg	Monoclonal Antibodies				￥4950.00	訂購(gòu) 詢價(jià)
3	Leading Biology	APR15980G	FGG Antibody	100 μl	Monoclonal Antibodies				￥5450.00	訂購(gòu) 詢價(jià)
4	Leading Biology	AMM05161G	GOB5 / CLCA1 Antibody (clone 1C4)	50 μg	Monoclonal Antibodies				￥5450.00	訂購(gòu) 詢價(jià)
5	Leading Biology	APR17667G	ORAI1 Antibody [3F6H5]	0.1 mg	Monoclonal Antibodies				￥6950.00	訂購(gòu) 詢價(jià)
6	Leading Biology	APR11118G	HIV-1 p24 Antibody [7F4] (biotin)	0.1 mg	Monoclonal Antibodies				￥6950.00	訂購(gòu) 詢價(jià)

最新加入的商品

最新加入的商品

全部產(chǎn)品分類