全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR17282G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MAP3K11 antibody (ascites).
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分子量 |
92688 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Note=Location is cell cycle dependent
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
This MAP3K11 monoclonal antibody is generated from mouse immunized with MAP3K11 recombinant protein.
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克隆號 |
230CT5.3.1
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亞型 |
IgM,k
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基因ID |
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UniProt ID |
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功能 |
Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.
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總結(jié) |
The protein encoded by this gene is a member of theserine/threonine kinase family. This kinase contains a SH3 domainand a leucine zipper-basic motif. This kinase preferentiallyactivates MAPK8/JNK kinase, and functions as a positive regulatorof JNK signaling pathway. This kinase can directly phosphorylate,and activates IkappaB kinase alpha and beta, and is found to beinvolved in the transcription activity of NF-kappaB mediated by Rhofamily GTPases and CDC42.
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形式 |
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:100~500
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別名 |
Mitogen-activated protein kinase kinase kinase 11, Mixed lineage kinase 3, Src-homology 3 domain-containing proline-rich kinase, MAP3K11 (HGNC:6850)
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圖像 |
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說明書 |
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數(shù)量 |
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