Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide

APR07251G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR07251G		50 μg / ￥3950

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Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide

品牌	Leading Biology	貨號	APR07251G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Bcl-2 (Apoptosis & Follicular Lymphoma Marker) antibody - With BSA and Azide.
分子量	25-26kDa
細胞定位	Antigen Cellular Localization: Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein
宿主	Mouse
種屬反應(yīng)性	Human
克隆號	SPM117
亞型	Mouse / IgG1, kappa
基因ID	596
UniProt ID	P10415
功能	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
總結(jié)	This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
形式	200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, FC
別名	Apoptosis regulator Bcl-2, BCL2
圖像	Formalin-fixed, paraffin-embedded human Non-Hodgkin's Lymphoma stained with Bcl-2 Ab (SPM117). Flow Cytometry of Jurkat cells using Bcl-2 Ab (SPM117) (red) and isotype control (green). Western Blot of Bcl-2 in human Skin using Bcl-2 Ab (SPM117).
說明書	Product Datasheet Protocol
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Bcl-2 (Apoptosis & Follicular Lymphoma Marker) Antibody - With BSA and Azide