Cytokeratin, pan (Epithelial Marker) Antibody - With BSA and Azide

APR14622G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR14622G		50 μg / ￥3950

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Cytokeratin, pan (Epithelial Marker) Antibody - With BSA and Azide

品牌	Leading Biology	貨號	APR14622G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Cytokeratin, pan (Epithelial Marker) antibody - With BSA and Azide.
分子量	40-60kDa
細胞定位	Antigen Cellular Localization: Cell membrane. Note=Located on plasma membrane of neuroblastoma NMB7 cells
宿主	Mouse
種屬反應(yīng)性	Human, Mouse, Rat
靶點	Human epidermal keratin
克隆號	AE-1/AE-3
亞型	IgG1+IgG1
通用名	KRTA
基因ID	3848
UniProt ID	P04264
功能	May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK.
總結(jié)	Twenty human keratins are resolved with two-dimensional gel electrophoresis into acidic (pI 6.0) subfamilies. This antibody cocktail recognizes acidic (Type I or LMW) and basic (Type II or HMW) cytokeratins, which include CK1, CK3, CK4, CK5, CK6, CK8, CK10, CK14, CK15, CK16, and CK19. Many studies have shown the usefulness of keratins as markers in cancer research and tumor diagnosis. AE-1/AE-3 is a broad spectrum anti pan-cytokeratin antibody cocktail, which differentiates epithelial tumors from non-epithelial tumors e.g. squamous vs. adenocarcinoma of the lung, liver carcinoma, breast cancer, and esophageal cancer. It has been used to characterize the source of various neoplasms and to study the distribution of cytokeratin containing cells in epithelia during normal development and during the development of epithelial neoplasms. This antibody stains cytokeratins present in normal and abnormal human tissues and has shown high sensitivity in the recognition of epithelial cells and carcinomas.
形式	0.5 ml at 200ug/ml with BSA and azide
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, IF, FC, IP
別名	Keratin, type II cytoskeletal 1, 67 kDa cytokeratin, Cytokeratin-1, CK-1, Hair alpha protein, Keratin-1, K1, Type-II keratin Kb1, KRT1, KRTA
圖像	Formalin-paraffin colon carcinoma stained with pan Cytokeratin Ab cocktail (AE-1 / AE3). Formalin-paraffin colon carcinoma stained with pan Cytokeratin Ab cocktail (AE-1 / AE3).
說明書	Product Datasheet Protocol
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Cytokeratin, pan (Epithelial Marker) Antibody - With BSA and Azide