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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR13800G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TRIB3 antibody.
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分子量 |
26722 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
A synthetic peptide corresponding to residues in human TRIB3 was used as an immunogen.
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克隆號(hào) |
EPR3150
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基因ID |
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UniProt ID |
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功能 |
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.
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總結(jié) |
Tribbles homolog 3 (Drosophila), TRIB3, is a putative protein kinase that has been implicated in the regulation of several biological processes in mammalian cells through its ability to influence Akt and other signaling pathways. It is an important negative regulator of adipogenesis because it acts at an early step in the differentiation cascade to block the C/EBP beta proadipogenic function. TRIB3 disrupts insulin signaling by binding directly to Akt and blocking activation of the kinase, thus contributing to insulin resistance in individuals with susceptibility to type II diabetes. TRIB3 expression is remarkably reduced in prostate cancer PC-3 cells after inhibition of phosphatidylinositol (PI) 3-kinase. The expression of TRIB3 is controlled by nutrient supplies, where the lack of glucose or amino acids results in a substantial increase in TRIB3 protein levels in a PI 3-kinase-dependent manner (1-3).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:500~1000
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別名 |
Complement C1q subcomponent subunit B, C1QB
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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