全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR13783G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TPPP antibody.
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分子量 |
23694 Da
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm. Cytoplasm, cytoskeleton. Nucleus. Note=Localizes to glial Lewy bodies in the brains of individuals with synucleinopathies
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點 |
A synthetic peptide corresponding to residues in human TPPP was used as an immunogen.
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克隆號 |
EPR3316
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通用名 |
TPPP1
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基因ID |
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UniProt ID |
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功能 |
May play a role in the polymerization of tubulin into microtubules, microtubule bundling and the stabilization of existing microtubules, thus maintaining the integrity of the microtubule network. May play a role in mitotic spindle assembly and nuclear envelope breakdown.
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總結(jié) |
Tubulin polymerization-promoting protein (TPPP) is an unfolded brain-specific protein that interacts with the tubulin/microtubule system, and is enriched in human pathological brain inclusions (1). TPPP can induce aggregation of alpha-synuclein, and can accumulate in oligodendroglial cell bodies containing fibrillized alpha-synuclein multiple system atrophy (MSA), a neurodegenerative disease. TPPP is a constituent of myelin and a high-affinity ligand for myelin basic protein (MBP), and has been shown to colocalize with MBP in myelin in normal human brains (2).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, IF
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稀釋方法 |
WB~~1:1000~10000
IHC~~1:250~500
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別名 |
Tubulin polymerization-promoting protein, TPPP, 25 kDa brain-specific protein, TPPP/p25, p24, p25-alpha, TPPP, TPPP1
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圖像 |
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說明書 |
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數(shù)量 |
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