全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM08147G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality TCP1 beta antibody.
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分子量 |
57488 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
A synthetic peptide corresponding to residues on the C-terminus in human TCP1 Beta was used as an immunogen.
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克隆號 |
EPR4084
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通用名 |
99D8.1, CCTB
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基因ID |
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UniProt ID |
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功能 |
Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
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總結(jié) |
T-complex polypeptide 1 subunit beta (TCP1 beta) is a cytosolic molecular chaperone that belongs to the chaperonin-containing TCP1 (CCT) complex (1). The CCT complex is composed of eight subunits that assist in the folding of actin, tubulin, and other cytosolic proteins (1). The sequence differences among the CCT subunits are located mainly in their apical domains, suggesting some degree of specificity towards substrate binding (2). TCP1 beta plays a role in the folding of newly translated proteins in the cytosol (3). Major cytoskeletal proteins such as actin and tubulin, depend on CCT to maintain the integrity of the microfilament and microtubule-based cytoskeletal systems (4). The beta-tubulin/TCP1 beta complex may serve as an effective chemotherapeutic target for treating tumors overexpressing TCP1 beta (5).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, IF
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稀釋方法 |
WB~~1:2000
IHC~~1:100~250
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別名 |
T-complex protein 1 subunit beta, TCP-1-beta, CCT-beta, CCT2, 99D81, CCTB
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圖像 |
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說明書 |
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數(shù)量 |
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