Synip Antibody

APR10366G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR10366G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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Synip Antibody

品牌	Leading Biology	貨號(hào)	APR10366G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Synip antibody.
分子量	61662 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A synthetic peptide corresponding to residues near the C-terminus of the PDZ domain of human Synip was used as immunogen. This antibody is predicted to detect the isoform 2 base on sequence analysis.
克隆號(hào)	EP302Y
基因ID	252983
UniProt ID	Q6ZWJ1
功能	Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose (By similarity).
總結(jié)	Synip (Syntaxin 4-Interacting protein) specifically binds to Syntaxin 4 and is uniquely expressed in muscle and adipose tissue. The binding interaction of Synip with syntaxin 4 is regulated by insulin, which also induces dissociation of the Synip-syntaxin 4 complex. Synip plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane and functions as a positive regulator of insulin-stimulated GLUT4 translocation. Synip also competes with VAMP2 but Not SNAP23 for binding to Syntaxin 4 (1-3).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:500~1000 IHC~~1:250~500
別名	Syntaxin-binding protein 4, Syntaxin 4-interacting protein, STX4-interacting protein, Synip, STXBP4
圖像	A. Western blot analysis on human skeletal muscle lysate using anti-Synip RabMAb (Cat. APR10366G), dilution 1:1,000. B. Immunohistochemical analysis of paraffin-embedded human lung carcinoma using anti-Synip RabMAb (Cat. APR10366G).
說(shuō)明書	Product Datasheet Protocol
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