全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM08012G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Stat-2 antibody.
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分子量 |
105417 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Translocated into the nucleus upon activation by IFN-alpha/beta.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Mouse
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靶點(diǎn) |
A synthetic peptide corresponding to residues near C-terminus of mouse Stat-2 was used as immunogen.
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克隆號 |
EP1814Y
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UniProt ID |
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功能 |
Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
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總結(jié) |
Stat-2 is a latent transcription factor that functions both as a signal transducer in the cytoplasm and an activator of transcription in the nucleus. Stat-2 is one of seven members of the Signal transducer and activators of transcription (Stats) family. Stat-2 is phosphorylated at Tyr690 by JAKs (1-3). Additionally, upon activation, Stat-2 will form a multi-protein DNA-binding complex with Stat-1 and ISGF3γp48 (4). This activation subsequently allows the complex to translocate to the nucleus & bind specific enhancer elements.
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:1000~2000
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別名 |
Signal transducer and activator of transcription 2, Stat2
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圖像 |
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說明書 |
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數(shù)量 |
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