SOD2 Antibody

APR10197G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR10197G		100 μl / ￥5450

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SOD2 Antibody

品牌	Leading Biology	貨號(hào)	APR10197G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SOD2 antibody.
分子量	24722 Da
細(xì)胞定位	Antigen Cellular Localization: Mitochondrion matrix.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A synthetic peptide corresponding to residues near the N-terminus of human SOD2 was used as an immunogen.
克隆號(hào)	EPR2560Y
基因ID	6648
UniProt ID	P04179
功能	Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
總結(jié)	Superoxide dismutase comprises a family of metalloenzymes that catalyze the oxido-reduction of superoxide anion to H2O2. Manganese superoxide dismutase (SOD2) is encoded by nuclear chromatin, synthesized in the cytosol, and imported posttranslationally into the mitochondrial matrix (1). It has been shown that SOD2 activity in tumor cells is lower than that in their normal counterparts. results suggest that the reduced level of SOD2 activity observed in human tumor cells is not due to a defect in the primary structure of the SOD2 protein, a change in the dosage of the SOD2 gene, or a decrease in the stability of SOD2 mRNA in tumor cells but rather is due to a defect or defects in the expression of the gene (2). SOD2 is one of the major cellular defense enzymes that protects against toxic effects of superoxide radicals. Overexpression of human SOD2 has been shown to inhibit radiation-induced neoplastic transformation, suppress malignancy of cancer cells, and increase tolerance to various toxic agents (3).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:1000~2000 IHC~~1:100~250
別名	Superoxide dismutase [Mn], mitochondrial, SOD2
圖像	A. Western blot analysis on (A) rat brain lysate using anti-SOD2 RabMAb, dilution 1:2000. (B)SH-SY5Y lysate using anti-SOD2 RabMAb (Cat. APR10197G), dilution 1:500. B. Immunohistochemical analysis of paraffin-embedded human liver using anti-SOD2 RabMAb (Cat. APR10197G).
說(shuō)明書(shū)	Product Datasheet Protocol
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