Radixin Antibody

AMM07508G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMM07508G		100 μl / ￥5450

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Radixin Antibody

品牌	Leading Biology	貨號(hào)	AMM07508G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Radixin antibody.
分子量	68564 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A synthetic peptide corresponding to residues near the N-terminus of human Radixin was used as an immunogen.
克隆號(hào)	EP1862Y
基因ID	5962
UniProt ID	P35241
功能	Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
總結(jié)	Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. Recent cloning of the murine and porcine radixin cDNAs revealed a protein highly homologous to ezrin and moesin (1). The ezrin-radixin-moesin (ERM) family of proteins crosslink actin filaments and integral membrane proteins. Radixin (encoded by Rdx) is the dominant ERM protein in the liver of wildtype mice and is concentrated at bile canalicular membranes (BCMs). Findings indicate that radixin is required for secretion of conjugated bilirubin through its support of Mrp2 localization at BCMs (2). Proteins of the ezrin-radixin-moesin family are ubiquitous constituents of the submembrane cortex, especially in epithelial cells. Radixin is thus a prominent constituent of stereocilia, where it may participate in anchoring the pointed ends of actin filaments to the membrane (3).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:1000~5000 IHC~~1:100~250
別名	Radixin, RDX
圖像	A. Western blot analysis on HeLa cell lysate using anti-Radixin RabMAb (Cat. AMM07508G), dilution 1:20,000. B. Immunohistochemical staining of paraffin-embedded human ovarian carcinoma using anti-Radixin RabMAb (Cat. AMM07508G).
說(shuō)明書(shū)	Product Datasheet Protocol
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