Prohibitin Antibody (N-term)

AMR09557G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMR09557G		100 μl / ￥5450

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Prohibitin Antibody (N-term)

品牌	Leading Biology	貨號(hào)	AMR09557G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Prohibitin antibody (N-term).
分子量	29804 Da
細(xì)胞定位	Antigen Cellular Localization: Mitochondrion inner membrane.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A synthetic peptide corresponding to residues on the N-terminus of human prohibitin was used as an immunogen.
克隆號(hào)	EP2803Y
基因ID	5245
UniProt ID	P35232
功能	Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging.
總結(jié)	Prohibitin (PHB) proteins have been ascribed various functions, including cell cycle regulation, apoptosis, assembly of mitochondrial respiratory chain enzymes, and aging. It has been shown that the mammalian prohibitins are present in the inner mitochondrial membrane and are always bound to each other, with no free protein detectable. They are coexpressed during development and in adult mammalian tissues, and expression levels are indicative of a role in mitochondrial metabolism, but are not compatible with roles in the regulation of cellular proliferation or apoptosis. Data support conserved roles for the prohibitins in regulating mitochondrial respiratory activity and in aging (1). Results suggest that prohibitin may be a tumor suppressor and is associated with tumor development and/or progression of at least some breast cancers (2).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:10,000~20,000 IHC~~1:250~500
別名	Prohibitin, PHB
圖像	A. Western blot analysis on (A) MCF-7 (B) A431, (C) 293T and Ramos cells. B. Immunohistochemical analysis of paraffin-embedded human kidney tissues using anti-Prohibitin RabMAb C. Immunohistochemical analysis of paraffin-embedded human hepatocellular carcinoma using anti-Prohibitin RabMAb (Cat. AMR09557G).
說(shuō)明書(shū)	Product Datasheet Protocol
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