Presenilin-2 Antibody Phospho (pS327)

AMR09512G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMR09512G		100 μl / ￥5450

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Presenilin-2 Antibody Phospho (pS327)

品牌	Leading Biology	貨號(hào)	AMR09512G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Presenilin-2 antibody Phospho (pS327).
分子量	50140 Da
細(xì)胞定位	Antigen Cellular Localization: Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A phospho specific peptide corresponding to residues surrounding serine 327 of human Presenilin 2 was used as an immunogen. This antibody detects Presenilin 2 phosphorylated on serine 327.
克隆號(hào)	EP2613Y
通用名	AD4, PS2, PSNL2, STM2
基因ID	5664
UniProt ID	P49810
功能	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins.
總結(jié)	Presenilin 1 (PS1) and Presenilin 2 (PS2) are transmembrane proteins which belong to Presenilin family, and their mutations are associated with early onset familial Alzheimer's disease. Presenilins facilitate gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Phosphorylation of the PS2 C-terminal fragments at serine residues 327 and 330, located immediately adjacent to the caspase recognition sites, inhibits caspase-mediated cleavage of PS2 and can regulate apoptotic cleavage. PS2 is cleaved by caspases during apoptosis between aspartate 329 and serine 330 (2).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB
稀釋方法	WB~~1:1000~5000
別名	Presenilin-2, PS-2, 3423-, AD3LP, AD5, E5-1, STM-2, Presenilin-2 NTF subunit, Presenilin-2 CTF subunit, PSEN2, AD4, PS2, PSNL2, STM2
圖像	A. Western blot analysis on HeLa cell lysates using anti-Phospho Presenilin 2 (pS327) RabMAb (Cat. AMR09512G), dilution 1:5,000. Cells were either (A) untreated (B) treated with AP.
說明書	Product Datasheet Protocol
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