Plectin Antibody

AMM07241G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMM07241G		100 μl / ￥5450

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Plectin Antibody

品牌	Leading Biology	貨號(hào)	AMM07241G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Plectin antibody.
分子量	531791 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, cytoskeleton. Cell junction, hemidesmosome
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A recombinant fragment comprising the C-terminal 220 amino acids of plectin was used as immunogen.
克隆號(hào)	E398P
通用名	PLEC1
基因ID	5339
UniProt ID	Q15149
功能	Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofibers integrity.
總結(jié)	Plectin, a 500-kDa intermediate filament binding protein, is localized to the cytoplasm and acts to both stabilize and give strength to cells via cross-linking (1). Plectin cross-links intermediate filaments to microtubules and microfilaments, and anchors intermediate filaments to the plasma and nuclear membranes (2,3). Plectin binds many proteins, including actin, vimentin, and Lamin B. Phosphorylation by PKA or PKC results in decreased binding to Lamin B, and phosphorylation by PKA enhances the plectin-vimentin interactions (4).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:1000~10000 IHC~~1:250
別名	Plectin, PCN, PLTN, Hemidesmosomal protein 1, HD1, Plectin-1, PLEC, PLEC1
圖像	A. Western blot analysis on Jurkat cell lysate using anti-Plectin RabMAb (Cat. AMM07241G), dilution 1:5,000. B. Immunohistochemical staining of paraffin-embedded human skeletal muscle using anti-Plectin RabMAb (Cat. AMM07241G).
說(shuō)明書(shū)	Product Datasheet Protocol
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