PLC-III Antibody Phospho (pS537)

AMR09342G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMR09342G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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PLC-III Antibody Phospho (pS537)

品牌	Leading Biology	貨號(hào)	AMR09342G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PLC-III antibody Phospho (pS537).
分子量	138799 Da
細(xì)胞定位	Antigen Cellular Localization: Membrane; Peripheral membrane protein.
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	A phosphor-specific peptide corresponding to residues surrounding Serine 537 of human PLC-β3 was used as an immunogen. This antibody detects PLC- β3 phosphorylated on Ser537.
克隆號(hào)	EPR1498Y
基因ID	5331
UniProt ID	Q01970
功能	The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
總結(jié)	PLC beta 3 plays an important role in initiating receptor-mediated signal transduction. Activation of PLC takes place in many cells as a response to stimulation by hormones, growth factors, neurotransmitters, and other ligands (1). PLCB3 plays an important role in signal transduction and, moreover, shows loss of expression in some endocrine tumors, in accordance with a putative tumor suppressor gene function (2). Morphine and other micro opioids regulate a number of intracellular signaling pathways, including the one mediated by phospholipase C (PLC). Data demonstrate that PLC beta3 constitutes a significant pathway involved in negative modulation of mu opioid responses, perhaps via protein kinase C, and suggests the possibility that differences in opioid sensitivity among individuals could be, in part, because of genetic factors (3).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB
稀釋方法	WB~~1:2000
別名	1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase beta-3, Phosphoinositide phospholipase C-beta-3, Phospholipase C-beta-3, PLC-beta-3, PLCB3
圖像	A. Western blot analysis on HeLa cell lysates using anti-Phospho-PLCB3 (pS537) RabMAb (Cat. AMR09342G), 1:2000 dilution. Cells were either (A) untreated or (B) treated with TPA.
說明書	Product Datasheet Protocol
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