全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR09199G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Phospho-PLC antibody gamma I.
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分子量 |
148532 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell projection, lamellipodium. Cell projection, ruffle. Note=Rapidly redistributed to ruffles and lamellipodia structures in response to epidermal growth factor (EGF) treatment
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
A synthetic peptide corresponding to phosphorylated residue surrounding tyrosine 1245 of human PLCγI was used.
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克隆號 |
EP1502Y
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通用名 |
PLC1
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基因ID |
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UniProt ID |
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功能 |
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand- mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
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總結(jié) |
The phospholipase C gamma-1 (PLCγI) is a member of phospholipase C family which catalyzes the hydrolysis of phospholipids to yield second messengers such as diacylglycerols (DAG) and water-soluble phosphorylated derivatives of the lipid head groups. These second messengers play a crucial role in transmembrane signaling and are involved in the regulation of several cellular functions, such as cell differentiation and proliferation (1). PLCγI interacts with variety of signaling molecules via its two SH2 domains and a single SH3 domain and it is activated by phosphorylation on Tyr783 through interaction with non-receptor and receptor tyrosine kinases. Interaction with activated receptors (e.g. PDGFR and EGFR) leads to phosphorylation on Tyr771, Tyr783, and Tyr1245 (2). Phosphorylations at Tyr783 and 1245 might be significant for adhesion PLCγI to fibronectin during integrin initiated fibronectin adhesion (3)
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:10000~50000
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別名 |
1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase gamma-1, PLC-148, Phosphoinositide phospholipase C-gamma-1, Phospholipase C-II, PLC-II, Phospholipase C-gamma-1, PLC-gamma-1, PLCG1, PLC1
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圖像 |
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說明書 |
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數(shù)量 |
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