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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > NF-H Antibody

NF-H Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
AMM06663G 100 μl / ¥5450

NF-H Antibody

品牌

Leading Biology

貨號(hào)

AMM06663G

產(chǎn)品分類

Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality NF-H antibody.

分子量

112479 Da

宿主

Rabbit

種屬反應(yīng)性

Human, Mouse, Rat

靶點(diǎn)

A synthetic peptide corresponding to residues in human NF-H was used as immunogen.

克隆號(hào)

EP673Y

通用名

KIAA0845, NFH

基因ID

UniProt ID

功能

Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.

總結(jié)

Neurofilaments (NF) are members of the intermediate filament protein family also known as 10nm filaments. These neuron-specific filaments are the major constituents of the axonal cytoskeleton (1). NFs are composed of three major proteins; NF-H, NF-L and NF-M and the ratio of each protein changes during neuronal development. NF-H is the heavy molecular weight protein (200 kDa), NF-M the medium (160 kDa) and NF-L the light protein (68kDa) (2). Phosphorylation of the NF-H tail domain modulates neurofilament transport, dynamics and organization within the axon. Accumulation of the protein or mutations in NF-H is observed during the progression of numerous neurological diseases such as amyotrophic lateral sclerosis (3).

形式

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC, IF

稀釋方法

WB~~1:500~2000 IHC~~1:500

別名

Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, Neurofilament triplet H protein, NEFH, KIAA0845, NFH

圖像

A. Western blot analysis on Rat Brain lysate using anti-NF-H RabMAb (Cat. AMM06663G), dilution 1:2,000.

B. Immunohistochemical analysis of paraffin embedded human brain glyoma using anti-NF-H RabMAb (Cat. AMM06663G).

C. Immunofluorescent staining of PC-12 cells using anti-NF-H RabMAb (Cat. AMM06663G).

說(shuō)明書

數(shù)量

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