全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR17368G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MIP-1 beta/CCL4 antibody (N-term).
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分子量 |
10212 Da
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細胞定位 |
Antigen Cellular Localization:
Secreted.
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宿主 |
Rabbit
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種屬反應性 |
Human
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靶點 |
A synthetic peptide corresponding to residues in the N-terminus of human MIP-1 beta/CCL4 was used as an immunogen.
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克隆號 |
EP521Y
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通用名 |
LAG1, MIP1B, SCYA4
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基因ID |
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UniProt ID |
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功能 |
Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B.
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總結 |
Macrophage inflammatory protein-1 beta (MIP-1 beta/CCL4) belongs to the intercrine beta (chemokine CC) family (1). MIP-1 beta functions to promote accumulation of lymphocyte, macrophages, monocytes, and NK cells during various inflammatory conditions through its chemotactic properties. MIP-1 beta is an essential inhibitor of cell infection by human immunodeficiency virus type 1 (HIV-1). MIP-1 beta inhibits HIV-1 by blocking or down-regulating the receptors CCR5, one coreceptor for HIV-1 entry (2). In human, MIP-1 beta exhibits specific attractant activities to CD4+ T lymphocytes, with minor activities to T cells from the naive (CD45RA) phenotype (3).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB
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稀釋方法 |
WB~~1:5000~10000
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別名 |
C-C motif chemokine 4, G-26 T-lymphocyte-secreted protein, HC21, Lymphocyte activation gene 1 protein, LAG-1, MIP-1-beta(1-69), Macrophage inflammatory protein 1-beta, MIP-1-beta, PAT 744, Protein H400, SIS-gamma, Small-inducible cytokine A4, T-cell activation protein 2, ACT-2, MIP-1-beta(3-69), CCL4, LAG1, MIP1B, SCYA4
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圖像 |
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說明書 |
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數(shù)量 |
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