MEKK3 Antibody (C-term)

APR17351G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR17351G		100 μl / ￥5450

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MEKK3 Antibody (C-term)

品牌	Leading Biology	貨號	APR17351G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MEKK3 antibody (C-term).
分子量	70898 Da
宿主	Rabbit
種屬反應(yīng)性	Human
靶點	A synthetic peptide corresponding to residues in the C-term of human MEKK3 was used as immunogen.
克隆號	EP600Y
通用名	MAPKKK3, MEKK3
基因ID	4215
UniProt ID	Q99759
功能	Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
總結(jié)	MEKK3 is a Ser/Thr protein kinase belonging to the MAP/ERK kinase kinase family (1). Closely related to MEKK2, MEKK3 is expressed in a multitude of tissues. MEKK3 directly regulates SAPKs and ERKs pathway via SEK and MEK1, respectively but not the p38 pathway (2) and is also involved in the NF-kB pathway (3). MEKK3 as well as MEKK2 bind, phosphorylate and activate MEK5 through their PB1 domain (4). hKSR-2 (human kinase suppressor of ras-2) has been shown to regulate the activity of MEKK3 (5).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, IF
稀釋方法	WB~~1:1000~5000 IHC~~1:100~250
別名	Mitogen-activated protein kinase kinase kinase 3, MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3, MAP3K3, MAPKKK3, MEKK3
圖像	A. Western blot analysis on Hela cell lysate using anti-MEKK3 (C-term) RabMAb (Cat. APR17351G), dilution 1:1,000. B. Immunohistochemical analysis of paraffin-embedded human ovary carcinoma using anti-MEKK3 (C-term) RabMAb (Cat. APR17351G). C. Immunofluorescent staining of HeLa cells using anti-MEKK3 (C-term) RabMAb (Cat. APR17351G).
說明書	Product Datasheet Protocol
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