全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR08116G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Lamin B Receptor antibody Receptor.
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分子量 |
70703 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus inner membrane; Multi-pass membrane protein
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Rat
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靶點(diǎn) |
A synthetic peptide corresponding to residues of human Lamin B Receptor was used as immunogen.
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克隆號(hào) |
E398L
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基因ID |
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UniProt ID |
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功能 |
Anchors the lamina and the heterochromatin to the inner nuclear membrane.
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總結(jié) |
Lamins are nuclear membrane proteins that serve to maintain specific cellular functions, such as DNA replication and chromatin organization (1). Lamin B receptor (LBR) is an integral protein of the nuclear envelope inner membrane. It is phosphorylated by CDC2 protein kinase in mitosis when the inner nuclear membrane breaks down into vesicles that dissociate from the lamina and the chromatin. It is phosphorylated by different protein kinases in interphase when the membrane is associated with these structures (2). The cleavage of lamins results in nuclear disregulation and cell death (3,4).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IF
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稀釋方法 |
WB~~1:5000
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別名 |
Lamin-B receptor, Integral nuclear envelope inner membrane protein, LMN2R, LBR
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圖像 |
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說明書 |
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數(shù)量 |
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