IRS-2 Antibody

APR08040G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR08040G		100 μl / ￥5450

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IRS-2 Antibody

品牌	Leading Biology	貨號(hào)	APR08040G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IRS-2 antibody.
分子量	137334 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, cytosol.
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	A synthetic peptide corresponding to residues surrounding Ser1203 of human IRS-2 was used as an immunogen.
克隆號(hào)	EP976Y
基因ID	8660
UniProt ID	Q9Y4H2
功能	May mediate the control of various cellular processes by insulin.
總結(jié)	Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). Sequences of IRS-2 and IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain and a phosphotyrosine-binding domain, and a poorly conserved carboxy terminus containing several tyrosine phosphorylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, and may be essential for signaling by several receptor systems such as insulin and cytokine (1).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:5000~20000 IHC~~1:100~250
別名	Insulin receptor substrate 2, IRS-2, IRS2
圖像	A. Western blot analysis on 293 cell lysate using anti-IRS-2 RabMAb (Cat. APR08040G), dilution 1:100,000 B. Immunohistochemical staining of paraffin-embedded human kidney using anti-IRS-2 RabMAb (Cat. APR08040G).
說(shuō)明書	Product Datasheet Protocol
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上一產(chǎn)品：IRS-4 Antibody (C-term) 下一產(chǎn)品：CD20 / MS4A1 (B-Cell Marker) Antibody - Culture Supernatant

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