CCR3/CKR3 Antibody (C-term)

APR15307G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR15307G		100 μl / ￥5450

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CCR3/CKR3 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	APR15307G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CCR3/CKR3 antibody (C-term).
分子量	41044 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse
靶點(diǎn)	A synthetic peptide corresponding to residues in C-terminal cytoplasmic domain of human CKR3 was used as immunogen. Predicted to cross-react with macaque, based on sequence homology.
克隆號(hào)	Y31
通用名	CMKBR3
基因ID	1232
UniProt ID	P51677
功能	Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
總結(jié)	CKR3, or C-C chemokine receptor type 3, is a G protein-coupled, seven-transmembrane domain receptor protein. The chemokine eotaxin appears to be a highly specific agonist for CKR3, making CKR3 one of the factors responsible for selective recruitment of eosinophils to sites of inflammation (1). It has been shown that more than one chemokine activates CKR3, including eotaxin, RANTES, and MCP-3 (2). Since CKR3 is prominently expressed in eosinophils, it has been named the human eosinophil eotaxin receptor (2,3).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	IHC~~1:100
別名	C-C chemokine receptor type 3, C-C CKR-3, CC-CKR-3, CCR-3, CCR3, CKR3, Eosinophil eotaxin receptor, CD193, CCR3, CMKBR3
圖像	A. Western blot analysis on (1) K562 and (2) Daudi cell lysates using anti-CCR3/CKR3 (C-term) RabMAb (Cat. APR15307G), dilution 1:500. B. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-CKR3/CCR3 (C-term) RabMAb (Cat. APR15307G).
說(shuō)明書(shū)	Product Datasheet Protocol
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