Huntingtin (HTT) Antibody

APR12411G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR12411G		100 μl / ￥5450

大規(guī)格詢價(jià)

2 Images

訂購信息

安諾倫（北京）生物科技有限公司

Tel: 400-965-8633
Tel: 010-56256916
Inquiry@annoron.com

全國授權(quán)代理商

Huntingtin (HTT) Antibody

品牌	Leading Biology	貨號	APR12411G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Huntingtin (HTT) antibody.
分子量	347603 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus. Note=The mutant Huntingtin protein colocalizes with AKAP8L in the nuclear matrix of Huntington disease neurons. Shuttles between cytoplasm and nucleus in a Ran GTPase-independent manner
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A synthetic peptide corresponding to residues specific to the apopain cleavage site of human huntingtin protein was used as an immunogen
克隆號	EP867Y
通用名	HD, IT15
基因ID	3064
UniProt ID	P42858
功能	May play a role in microtubule-mediated transport or vesicle function.
總結(jié)	Huntingtin protein (Htt) is a 348 kDa protein product of Huntingtons disease (HD, IT15) gene. Huntingtons disease is a neurodegenerative disorder caused by a mutation on the HD gene, producing a polyglutamin (polyQ) expansion on the N-terminus of Htt. The mutant Htt leads to cytotoxicity in the striatal neuron (1). This cytotoxicity is modulated by proteolytic cleavage with caspases and calpains, producing N-terminal polyQ fragments. A phosphorylation of Htt may also regulate the cleavage and cytotoxicity of mutant Htt (2). The wild-type Htt up-regulates transcription of brain-derived neurotrophic factor (BDNF), a pro-survival factor for striatal neurons. This suggests restoring wild-type Htt level and increasing BDNF expression level can be therapeutic treatment for Huntingtons disease (3). Huntingtin is also cleaved by apopain, a cysteine protease product of death-gene for human, suggesting HD might be a disorder of inappropriate apoptosis (4).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:1000~10000 IHC~~1:250~500
別名	Huntingtin, Huntington disease protein, HD protein, HTT, HD, IT15
圖像	A. Western blot analysis on SH-SY-5Y cell lysate using anti-huntingtin RabMAb (Cat. APR12411G), dilution 1:10,000. B. Immunohistochemical analysis of paraffin-embedded human brain tissue using RabMAb. (Cat. APR12411G).
說明書	Product Datasheet Protocol
數(shù)量

加入購物車詢價(jià)

上一產(chǎn)品：IL-1 beta Antibody 下一產(chǎn)品：CD20 / MS4A1 (B-Cell Marker) Antibody - Culture Supernatant

熱銷產(chǎn)品

產(chǎn)品添加成功！

購物車已有 0 件產(chǎn)品

繼續(xù)訂購查看訂購單

加入詢價(jià)單成功！

詢價(jià)單已有 0 件產(chǎn)品

繼續(xù)詢價(jià) 查看詢價(jià)單

選擇	品牌	貨號	產(chǎn)品名稱	規(guī)格	分類	研究領(lǐng)域	說明書	數(shù)量	目錄價(jià)
1	Leading Biology	APG01369G	VEGF (Vascular Endothelial Growth Factor) Antibody - Without BSA and Azide	100 μg	Monoclonal Antibodies				￥4950.00	訂購詢價(jià)
2	Leading Biology	AMM07627G	RIN2 Antibody (monoclonal) (M01)	100 μg	Monoclonal Antibodies				￥4950.00	訂購詢價(jià)
3	Leading Biology	APR15980G	FGG Antibody	100 μl	Monoclonal Antibodies				￥5450.00	訂購詢價(jià)
4	Leading Biology	AMM05161G	GOB5 / CLCA1 Antibody (clone 1C4)	50 μg	Monoclonal Antibodies				￥5450.00	訂購詢價(jià)
5	Leading Biology	APR17667G	ORAI1 Antibody [3F6H5]	0.1 mg	Monoclonal Antibodies				￥6950.00	訂購詢價(jià)
6	Leading Biology	APR11118G	HIV-1 p24 Antibody [7F4] (biotin)	0.1 mg	Monoclonal Antibodies				￥6950.00	訂購詢價(jià)

最新加入的商品

最新加入的商品

全部產(chǎn)品分類