全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR16686G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Hex antibody.
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分子量 |
30022 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點 |
A synthetic peptide corresponding to residues in human Hex was used as an immunogen.
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克隆號 |
EPR3361
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通用名 |
HEX, PRH, PRHX
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基因ID |
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UniProt ID |
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功能 |
Recognizes the DNA sequence 5'-ATTAA-3'. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity).
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總結(jié) |
Hex, the hematopoietically-expressed homeobox protein (proline-rich homeodomain protein/PRH) is a transcription factor that is important in the control of cell proliferation and differentiation and in the regulation of multiple processes in embryonic development. Hex contains two domains that can independently bring about transcriptional repression. The Hex homeodomain represses transcription by binding to TATA box sequences, whereas the proline-rich N-terminal domain of Hex can repress transcription when attached to a heterologous DNA-binding domain (1). Hex is expressed in primitive endoderm, in some endoderm-derived tissues and in endothelial and hematopoietic precursors. Expression is extinguished during terminal differentiation of endothelial and hematopoietic cells as well as in adult lung (2).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:1000~5000
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別名 |
Hematopoietically-expressed homeobox protein HHEX, Homeobox protein HEX, Homeobox protein PRH, HHEX, HEX, PRH, PRHX
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圖像 |
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說明書 |
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數(shù)量 |
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