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當(dāng)前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > GAD2 Antibody

GAD2 Antibody

貨號 貨期 規(guī)格 / 價(jià)格 詢價(jià)
AMM04668G 100 μl / ¥5450

GAD2 Antibody

品牌

Leading Biology

貨號

AMM04668G

產(chǎn)品分類

Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GAD2 antibody.

分子量

65411 Da

細(xì)胞定位

Antigen Cellular Localization: Cytoplasm, cytosol. Cytoplasmic vesicle. Cell junction, synapse, presynaptic cell membrane; Lipid-anchor. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters

宿主

Rabbit

種屬反應(yīng)性

Human, Mouse, Rat

靶點(diǎn)

A synthetic peptide corresponding to residues in human GAD2 was used as an immunogen.

克隆號

EPR2553Y

通用名

GAD65

基因ID

UniProt ID

功能

Catalyzes the production of GABA.

總結(jié)

Glutamate decarboxylase (GAD) catalyzes the production of gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter. GAD is represented by two isoforms, GAD1 and GAD2, which are the products of two different genes and differ substantially only at their N-terminal regions. In neurons and beta cells, GAD is concentrated around synaptic vesicles and synaptic-like microvesicles, respectively, as well as in the area of the Golgi complex. GAD2 lies primarily in axon terminals and only about half of GAD2 exists as active holoenzyme (1-2). The beta cell-specific marker GAD2 can be quantified in pancreatic cell extracts and in serum (3). GAD2 is a major target for autoantibodies and autoreactive T cells in patients with insulin-dependent diabetes mellitus. Autoantibodies to GAD are also found in patients with stiff man syndrome or polyendocrine autoimmunity (4).

形式

50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB

稀釋方法

WB~~1:500~2000

別名

Glutamate decarboxylase 2, 65 kDa glutamic acid decarboxylase, GAD-65, Glutamate decarboxylase 65 kDa isoform, GAD2, GAD65

圖像

A. Western blot analysis on (A) fetal brain, (B) mouse brain and (C) rat brain lysates using anti-GAD2 RabMAb (Cat. AMM04668G), dilution 1:1000.

說明書

數(shù)量

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