全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR07718G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ENTPD5 antibody.
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分子量 |
47517 Da
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細胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum. Secreted
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點 |
A synthetic peptide corresponding to residues in human ENTPD5 was used as an immunogen.
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克隆號 |
EPR3738
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通用名 |
CD39L4, PCPH
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基因ID |
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UniProt ID |
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功能 |
Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.
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總結(jié) |
The ecto-nucleoside triphosphate diphosphohydrolases (eNTPDases) are a family of enzymes that control extracellular nucleotide levels thereby regulating purinergically controlled physiological processes. Six of the eight known NTPDases are membrane-bound and only ENTD5 and 6 can be released as soluble enzymes (1). ENTPD5 promotes reglycosylation reactions involved in glycoproteins folding and quality control in the endoplasmic reticulum. It also hydrolyzes UDP, GDP and IDP but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate (2). ENTPD5 is expressed in adult liver, kidney, prostate, testis and colon (1).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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稀釋方法 |
WB~~1:1000~5000
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別名 |
Ectonucleoside triphosphate diphosphohydrolase 5, NTPDase 5, CD39 antigen-like 4, ER-UDPase, Guanosine-diphosphatase ENTPD5, GDPase ENTPD5, Nucleoside diphosphatase, Uridine-diphosphatase ENTPD5, UDPase ENTPD5, ENTPD5, CD39L4, PCPH
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圖像 |
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說明書 |
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數(shù)量 |
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