全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM05710G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CCT-alpha antibody.
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分子量 |
41731 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytosol. Membrane; Peripheral membrane protein. Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點 |
A synthetic peptide corresponding to residues in human CCT-alpha was used as an immunogen.
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克隆號 |
EPR3941
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通用名 |
CTPCT, PCYT1
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基因ID |
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UniProt ID |
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功能 |
Controls phosphatidylcholine synthesis.
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總結(jié) |
CTP:phosphocholine cytidylyltransferase (CCT) is the key regulator enzyme in the synthesis of phosphatidylcholine (PC), the most abundant phospholipid in eukaryotic cell membranes. CCT catalyzes the transfer of a cytidylyl group from CTP to phosphocholine to form CDP-choline (1). A steady, albeit low, production of PC is necessary to maintain suitable PC content for lipid homeostasis. However, elevated activity of CCT is required during cell division when increased PC production is needed for membrane biogenesis (2). To date, three CCT isoforms have been identified: CCT-alpha, CCT-beta 1, and CCT-beta 2 (3). CCT-alpha is localized to the nucleus and nuclear envelope in many cell types. An exception is lung-derived cell, where CCT-alpha is localized primarily in cytoplasmic and ER compartments. CCT-alpha is involved in important nuclear functions such as coordinating PC synthesis with cell-cycle regulation and regulating proliferation of the nucleoplasmic reticulum, an intranuclear membrane network implicated in calcium signaling and nuclear-cytoplasmic transport (4).
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形式 |
50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IF
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稀釋方法 |
WB~~1:1000~10000
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別名 |
Choline-phosphate cytidylyltransferase A, CCT-alpha, CTP:phosphocholine cytidylyltransferase A, CCT A, CT A, Phosphorylcholine transferase A, PCYT1A, CTPCT, PCYT1
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圖像 |
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說明書 |
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數(shù)量 |
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