Catalase Antibody

APG02434G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APG02434G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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Catalase Antibody

品牌	Leading Biology	貨號(hào)	APG02434G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Catalase antibody.
分子量	59756 Da
細(xì)胞定位	Antigen Cellular Localization: Peroxisome.
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A synthetic peptide corresponding to residues near the N-terminus of human Catalase was used as an immunogen.
克隆號(hào)	EPR1928Y
基因ID	847
UniProt ID	P04040
功能	Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.
總結(jié)	Human catalase is an heme-containing peroxisomal enzyme that breaks down hydrogen peroxide to water and oxygen; it is implicated in ethanol metabolism, inflammation, apoptosis, aging and cancer. The 1. 5 A resolution human enzyme structure, both with and without bound NADPH, establishes the conserved features of mammalian catalase fold and assembly, implicates Tyr370 as the tyrosine radical, suggests the structural basis for redox-sensitive binding of cognate mRNA via the catalase NADPH binding site, and identifies an unexpectedly substantial number of water-mediated domain contacts (1). Because catalase has a low affinity for H2O2, it has been suggested that glutathione peroxidase clears most H2O2 within the erythrocyte and that catalase is of little import. It has been hypothesized that erythrocyte catalase might function to protect heterologous somatic cells against challenge by high levels of exogenous H2O2 (e.g., in areas of inflammation) (2).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC, WB
稀釋方法	IHC~~1:100~250 WB~~1:500~1000
別名	Catalase, CAT
圖像	B. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Catalase RabMAb (Cat. APG02434G). A. Western blot analysis on (A) TF-1 (B) HeLa (C) Jurkat (D) HepG2 cell lysates using anti-Catalase RabMAb (Cat. APG02434G), dilution 1:1000.
說明書	Product Datasheet Protocol
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