Caspase-9 Antibody (Pro)

APG02421G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APG02421G		100 μl / ￥5450

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Caspase-9 Antibody (Pro)

品牌	Leading Biology	貨號	APG02421G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Caspase-9 antibody (Pro).
分子量	46281 Da
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點	A synthetic peptide corresponding to residues near N-terminus of human Caspase-9 was used as immunogen. This antibody only recognises the Pro form of Caspase-9 (46kDa).
克隆號	E84
通用名	MCH6
基因ID	842
UniProt ID	P55211
功能	Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP- ribose) polymerase (PARP).
總結(jié)	Caspase-9 (ICE-LAP6, Mch-6, Apaf-3) is a member of the cysteine aspartic acid protease, or caspase, family. Pro-Caspase-9 exists as a 46 kDa isomer that is cleaved by apoptotic stimulation, and functions as the major initiator caspase in programmed cell death, or apoptosis (1-4). Upon stimulation, cytochrome c is released from mitochondria, and associates with the Pro-Caspase-9/Apaf 1 complex. This complex in turn activates Pro-Caspase-9 by cleaving it into an active 35 kDa fragment and a small 10 kDa fragment (1,2). Activated Caspase-9 cleaves Caspase-3 as well as poly (ADP-ribose) polymerase (PARP) to initiate a caspase cascade and apoptosis (3,4).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, FC
稀釋方法	WB~~1:500~2000 IHC~~1:25 FC~~1:50
別名	Caspase-9, CASP-9, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, APAF-3, ICE-like apoptotic protease 6, ICE-LAP6, Caspase-9 subunit p35, Caspase-9 subunit p10, CASP9, MCH6
圖像	A. Western blot analysis on Jurkat cell lysate using anti-Pro-Caspase-9 RabMAb (Cat. APG02421G), 1:1,000 dilution. B. Immunohistochemical analysis of paraffin-embedded human colon adenocarcinoma using anti-Pro-Caspase-9 RabMAb (Cat. APG02421G). C. Flow cytometric analysis of permeabilized HeLa cells using anti-Pro-Caspase-9 RabMAb (red) (Cat. APG02421G) or a rabbit IgG (negative) (green).
說明書	Product Datasheet Protocol
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