Caspase-7 Antibody

APG02395G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APG02395G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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Caspase-7 Antibody

品牌	Leading Biology	貨號(hào)	APG02395G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Caspase-7 antibody.
分子量	34277 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm.
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	A synthetic peptide corresponding to residues near N-terminus of human Caspase-7 was used as immunogen. The antibody should recognize both pro-form and p20 cleaved-form. The antibody does not cross-react with other Caspase family members.
克隆號(hào)	E22
通用名	MCH3
基因ID	840
UniProt ID	P55210
功能	Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly- 217' bond. Overexpression promotes programmed cell death.
總結(jié)	Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. Caspase-7 (CMH-1, Mch3, ICE-LAP3) is an effector caspase involved in the activation cascade for apoptosis execution (1,2,3). Pro-Caspase-7 is a 35-kDa protein localized to the cytoplasm and expressed in a variety of tissues and cell lines (1). Upon activation, Caspase-7 is translocated to the mitochondria, and proceeds to proteolytically cleave poly(ADP-ribose) polymerase (PARP) (2,3) and endoplasmic reticular-specific substrate, sterol regulatory element-binding protein 1 (4).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, IF
稀釋方法	WB~~1:5000~20000 IHC~~1:50~100
別名	Caspase-7, CASP-7, Apoptotic protease Mch-3, CMH-1, ICE-like apoptotic protease 3, ICE-LAP3, Caspase-7 subunit p20, Caspase-7 subunit p11, CASP7, MCH3
圖像	A. Western blot analysis of Jurkat cell lysate using anti Caspase 7 RabMab 1032 -1 B.Immunohistochemical analysis of_paraffin embedded human skin cancer tissue using anti Caspase 7 RabMab catalog 1032 -1 C. Immunofluorescent staining of HeLa cells using anti Caspase 7 RabMab 1032 -1
說明書	Product Datasheet Protocol
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