AMACR Antibody

APG01834G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APG01834G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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AMACR Antibody

品牌	Leading Biology	貨號(hào)	APG01834G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality AMACR antibody.
分子量	42387 Da
細(xì)胞定位	Antigen Cellular Localization: Peroxisome. Mitochondrion
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	A synthetic peptide corresponding to residues in human AMACR was used as an immunogen.
克隆號(hào)	EPR3717
基因ID	23600
UniProt ID	Q9UHK6
功能	Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.
總結(jié)	Alpha-methylacyl-CoA racemase (AMACR) primary role involves the racemization of 2-methyl-branched fatty acid CoA esters and the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers (1). A central role in all the metabolic pathways is played by AMACR, which regulates metabolism of lipids. AMACR regulates the entry of branched-chain lipids into the peroxisomal and mitochondrial beta-oxidation pathways (2). It has also been proven to be one of the few biomarkers that can help distinguish cancer from benign cells, with high sensitivity and specificity for prostate carcinoma (3). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) that results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa and epilepsy (1).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC
稀釋方法	WB~~1:1000~5000 IHC~~1:100~250
別名	Alpha-methylacyl-CoA racemase, 2-methylacyl-CoA racemase, AMACR
圖像	Western blot analysis on (A) LNCaP (B) HepG2 cell lysate (C) Mouse heart (D) Mouse kidney and (E) Rat kidney lysates using anti-AMACR RabMAb (Cat. APG01834G). Immunohistochemical analysis of paraffin-embedded human prostatic adenocarcinoma using antyi-AMACR RabMAb (Cat. APG01834G).
說明書	Product Datasheet Protocol
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