Acetyl-CoA1 (ACC1) Antibody Phospho-pS79

APG01484G Product Datasheet Protocol

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APG01484G		100 μl / ￥5450

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Acetyl-CoA1 (ACC1) Antibody Phospho-pS79

品牌	Leading Biology	貨號(hào)	APG01484G
產(chǎn)品分類	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Acetyl-CoA1 (ACC1) antibody Phospho-pS79.
分子量	265554 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm.
宿主	Rabbit
種屬反應(yīng)性	Human
靶點(diǎn)	A phospho specific peptide corresponding to residues surrounding serine 79 of human ACC1 was used as an immunogen. This antibody detects ACC1 phosphorylated at serine 79.
克隆號(hào)	EP1885Y
通用名	ACAC, ACC1, ACCA
基因ID	31
UniProt ID	Q13085
功能	Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
總結(jié)	Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK at Ser79 and others) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).
形式	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB
稀釋方法	WB~~1:10000~50000
別名	Acetyl-CoA carboxylase 1, ACC1, ACC-alpha, Biotin carboxylase, ACACA, ACAC, ACC1, ACCA
圖像	A. Western blot analysis on A431 cell lysates using anti-Phospho-ACC1 (pS79) RabMAb (Cat. APG01484G), 1:10,000 dilution. Cells were either (A) untreated (B) treated with LP
說明書	Product Datasheet Protocol
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