FOXO3 / FOXO3A Antibody (clone 4F2)

AMM02088G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMM02088G		50 μg / ￥5450

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安諾倫（北京）生物科技有限公司

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FOXO3 / FOXO3A Antibody (clone 4F2)

品牌	Leading Biology	貨號(hào)	AMM02088G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FOXO3 / FOXO3A Antibody (clone 4F2).
分子量	71kDa
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm, cytosol. Nucleus. Note=Translocates to the nucleus upon oxidative stress and in the absence of survival factors
宿主	Mouse
種屬反應(yīng)性	Human
靶點(diǎn)	Human FOXO3
克隆號(hào)	4F2
通用名	FKHRL1, FOXO3A
基因ID	2309
UniProt ID	O43524
功能	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
總結(jié)	Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post- transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF, E
稀釋方法	IF (10 μg/ml), IHC-P (5 μg/ml), WB (1:500-1:1000)
圖像	Immunofluorescence of monoclonal antibody to FOXO3 on HeLa cell. [antibody concentration 10 ug/ml]. Anti-FOXO3A antibody IHC of human spleen.
說(shuō)明書(shū)	Product Datasheet Protocol
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上一產(chǎn)品：FOXO3 / FOXO3A Antibody (clone 2C5) 下一產(chǎn)品：CD20 / MS4A1 (B-Cell Marker) Antibody - Culture Supernatant

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