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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > CBFA1 / RUNX2 Antibody (clone 1D2)

CBFA1 / RUNX2 Antibody (clone 1D2)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
AMM01908G 50 μg / ￥5450

CBFA1 / RUNX2 Antibody (clone 1D2)

品牌

 Leading Biology

貨號(hào)

 AMM01908G

產(chǎn)品分類(lèi)

 Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CBFA1 / RUNX2 Antibody (clone 1D2).

分子量
57kDa

細(xì)胞定位
Antigen Cellular Localization: Nucleus.

宿主
Mouse

種屬反應(yīng)性
Human

克隆號(hào)
1D2

通用名
AML3, CBFA1, OSF2, PEBP2A

基因ID

UniProt ID

功能
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

總結(jié)
Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'- PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC-P, IF, E

稀釋方法
IF (10 μg/ml), IHC-P (5 μg/ml),

圖像

Immunofluorescence of monoclonal antibody to RUNX2 on HeLa cell (antibody concentration 10 ug/ml).

Anti-RUNX2 antibody IHC of human prostate.

Anti-RUNX2 antibody IHC of human uterus.

說(shuō)明書(shū)

數(shù)量

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