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當(dāng)前位置：首頁 > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > SORL1 Antibody

SORL1 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
AMM02650G 100 μl / ￥5450

SORL1 Antibody

品牌

 Leading Biology

貨號(hào)

 AMM02650G

產(chǎn)品分類

 Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SORL1 Antibody.

分子量
248426 Da

細(xì)胞定位
Antigen Cellular Localization: Membrane; Single-pass type I membrane protein. Golgi apparatus. Endosome Secreted

宿主
Mouse

種屬反應(yīng)性
Human

克隆號(hào)
7D7B11

亞型
IgG1

通用名
C11orf32

基因ID

UniProt ID

功能
Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction. Involved in APP trafficking to and from the Golgi apparatus. It probably acts as a sorting receptor that protects APP from trafficking to late endosome and from processing into amyloid beta, thereby reducing the burden of amyloidogenic peptide formation. Involved in the regulation of smooth muscle cells migration, probably through PLAUR binding and decreased internalization.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, E

稀釋方法
WB~~1/500 - 1/2000 IHC~~1:200~~1000

圖像

Figure 1: Western blot analysis using SORL1 mouse mAb against truncated SORL1 recombinant protein (1) and SORL1 (aa2159-2214)-hIgGFc transfected CHO-K1 cell lysate (2).

Figure 2: Immunohistochemical analysis of paraffin-embedded human ovary carcinoma (A), normal cerebrum tissues (B), breast infiltrating carcinoma (C) and breast infiltrating carcinoma (D), showing cytoplasmic localization using STYK1/NOK mouse mAb with DAB staining.

說明書

數(shù)量

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