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LGR5 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
AMM03068G 100 μl / ￥5450

LGR5 Antibody

品牌

 Leading Biology

貨號(hào)

 AMM03068G

產(chǎn)品分類

 Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality LGR5 Antibody.

分子量
100kDa

細(xì)胞定位
Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Multi-pass membrane protein. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. Internalization to the trans- Golgi network may be the result of phosphorylation at Ser-861 and Ser-864; however, the phosphorylation event has not been proven (PubMed:23439653).

宿主
Mouse

種屬反應(yīng)性
Human

克隆號(hào)
2B5B9

亞型
IgG2b

通用名
GPR49, GPR67

基因ID

UniProt ID

功能
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC, FC, ICC, E

稀釋方法
E~~1/10000 WB~~1/500 - 1/2000 FC~~1/200 - 1/400

圖像

Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng);

Figure 2:Western blot analysis using LGR5 mAb against human LGR5 (AA: 22-178) recombinant protein. (Expected MW is 43.4 kDa)

Figure 3:Western blot analysis using LGR5 mAb against HEK293 (1) and LGR5 (AA: 22-178)-hIgGFc transfected HEK293 (2) cell lysate.

說(shuō)明書

數(shù)量

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