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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > MAP2K4 Antibody

MAP2K4 Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
AMM02822G 100 μl / ￥5450

MAP2K4 Antibody

品牌

 Leading Biology

貨號(hào)

 AMM02822G

產(chǎn)品分類(lèi)

 Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality MAP2K4 Antibody.

分子量
42kDa

細(xì)胞定位
Antigen Cellular Localization: Cytoplasm. Nucleus

宿主
Mouse

種屬反應(yīng)性
Human

克隆號(hào)
5H4

亞型
IgG1

通用名
JNKK1, MEK4, MKK4, PRKMK4, SEK1, SERK1,

基因ID

UniProt ID

功能
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC, FC, E

稀釋方法
E~~1/10000 WB~~1/500 - 1/2000 IHC~~1/500 - 1/2000 FC~~1/200 - 1/400

圖像

Red: Control Antigen (100ng);Purple: Antigen (10ng);Green: Antigen (50ng);Blue: Antigen (100ng);

Figure 1: Western blot analysis using MAP2K4 mouse mAb against HepG2 (1), K562 (2), and HEK293 (3) cell lysate.

Figure 2: Immunohistochemical analysis of paraffin-embedded muscle tissues using MAP2K4 mouse mAb with DAB staining.

說(shuō)明書(shū)

數(shù)量

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