全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
AMM02813G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PDK1 Antibody.
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分子量 |
44kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Mitochondrion matrix
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human, Rat, Monkey
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克隆號(hào) |
4A11
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亞型 |
IgG1
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通用名 |
PDHK1
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基因ID |
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UniProt ID |
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功能 |
Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, FC, ICC, E
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稀釋方法 |
WB~~1/500 - 1/2000
IHC~~1/200 - 1/1000
IF~~1/200 - 1/1000
FC~~1/200 - 1/400
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圖像 |
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說明書 |
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數(shù)量 |
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