AKT3 Antibody (clone 9H8)

AMM02301G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
AMM02301G		50 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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AKT3 Antibody (clone 9H8)

品牌	Leading Biology	貨號(hào)	AMM02301G
產(chǎn)品分類(lèi)	Monoclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality AKT3 Antibody (clone 9H8).
分子量	55775 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation
宿主	Mouse
種屬反應(yīng)性	Human, Mouse
靶點(diǎn)	Human AKT3
克隆號(hào)	9H8
亞型	IgG3
通用名	PKBG
基因ID	10000
UniProt ID	Q9Y243
功能	AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis.
總結(jié)	AKT3 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase- dependent apoptosis.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, IF
稀釋方法	IF (1:100), IHC-P (10 μg/ml), WB (1:500),
圖像	Anti-AKT3 antibody IHC staining of human kidney. Immunofluorescent staining of HeLa cells using anti-AKT3 mouse monoclonal antibody. Anti-AKT3 mouse monoclonal antibody immunofluorescent staining of HeLa cells transiently...
說(shuō)明書(shū)	Product Datasheet Protocol
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