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> 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > MCAM / CD146 Antibody (aa84-189, clone 6C3E6)品牌 |
Leading Biology | 貨號(hào) |
AMM02239G |
產(chǎn)品分類 |
Monoclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MCAM / CD146 Antibody (aa84-189, clone 6C3E6).
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分子量 |
72kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Membrane; Single-pass type I membrane protein
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宿主 |
Mouse
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
Human MCAM / CD146
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克隆號(hào) |
6C3E6
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通用名 |
MUC18
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基因ID |
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UniProt ID |
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功能 |
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
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總結(jié) |
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E, Flo
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稀釋方法 |
ELISA (1:10000), Flo (1:200-1:400), IHC-P (10 μg/ml), WB (1:500-1:2000) ,
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圖像 |
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說明書 |
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數(shù)量 |
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