全部產品分類
品牌 |
Leading Biology | 貨號 |
AMM01974G |
產品分類 |
Monoclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality IL16 Antibody (clone G11/II).
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分子量 |
142kDa
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細胞定位 |
Antigen Cellular Localization:
Interleukin-16: Secreted. Isoform 3: Cytoplasm. Nucleus.
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宿主 |
Mouse
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種屬反應性 |
Human
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靶點 |
G11/II detects LCF, a homotetrameric glycoprotein of 56kDa molecular weight that is composed of four noncovalently linked peptides of 14 kDa. Specificity: Human: LCF (IL-16). Other species: not tested.
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克隆號 |
G11/II
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基因ID |
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UniProt ID |
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功能 |
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
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總結 |
Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T- cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
IHC-P
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稀釋方法 |
IHC-P (5 μg/ml)
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圖像 |
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說明書 |
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數量 |
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