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當前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Monoclonal Antibodies > IKBKG / NEMO / IKK Gamma Antibody (clone 46B844)

IKBKG / NEMO / IKK Gamma Antibody (clone 46B844)

貨號 貨期 規(guī)格 / 價格 詢價
AMM01958G 50 μg / ¥4950

IKBKG / NEMO / IKK Gamma Antibody (clone 46B844)

品牌

Leading Biology

貨號

AMM01958G

產(chǎn)品分類

Monoclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality IKBKG / NEMO / IKK Gamma Antibody (clone 46B844).

分子量

48kDa

細胞定位

Antigen Cellular Localization: Cytoplasm. Nucleus. Note=Sumoylated NEMO accumulates in the nucleus in response to genotoxic stress

宿主

Mouse

種屬反應(yīng)性

Human

靶點

A His-tagged full-length human IKK3/IKKg protein.

克隆號

46B844

通用名

FIP3, NEMO

基因ID

UniProt ID

功能

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

總結(jié)

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'- linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B- mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination.

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC-P, Flo

稀釋方法

IHC-P (10 μg/ml), WB (2 μg/ml),

圖像

Western blot of 30 ug of total cell lysate from Jurkat cells with antibody at 2 ug/ml dilution.

Anti-IKBKG / IKK Gamma antibody IHC of human prostate.

說明書

數(shù)量

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